A Secret Weapon For modafinil dosage
iloperidone will increase levels of modafinil by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Check. Iloperidone is really a time-dependent CYP3A inhibitor and could bring on amplified plasma amounts of prescription drugs predominantly eradicated by CYP3A4.
Other variables that can be found in include things like affected person dimension, how reactive They're to your drug, and how often they’re taking it.
The recommended dosage of PROVIGIL for patients with narcolepsy or OSA is 200 mg taken orally once a day as one dose each morning.
When you find yourself getting this medicine, it is especially essential that your Health care Experienced know Should you be having any of your medicines listed below. The subsequent interactions are selected on The idea in their opportunity importance and are not necessarily all-inclusive.
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Medications that have limitations other than prior authorization, quantity limits, and phase therapy connected with Each individual prescription.
[18] Serious renal and/or hepatic impairment is known to trigger significantly elevated constant-point out drug concentrations. Dose reduction is recommended in patients with extreme hepatic impairment.
Voxelotor improves systemic exposure of sensitive CYP3A4 substrates. Stay clear of coadministration with sensitive CYP3A4 substrates having a slender therapeutic index. Think about dose reduction with the sensitive CYP3A4 substrate(s) if struggling to keep away from.
apalutamide will minimize the extent or impact of modafinil by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Stay away from or Use Alternate Drug. Coadministration of apalutamide, a strong CYP3A4 inducer, with drugs which are CYP3A4 substrates may end up in decreased publicity to these prescription drugs.
triclabendazole will improve the level or outcome of modafinil by influencing hepatic enzyme CYP2C19 metabolism.
In addition to its affect on dopaminergic pathways, modafinil may affect other neurotransmitter systems, for instance orexin or hypocretin.[a hundred and forty four] Orexin neurons Perform an important role in marketing wakefulness and regulating arousal states.
Allergic reactions including rash, angioedema, anaphylaxis, and Stevens–Johnson syndrome may be activated by an immunological response to modafinil or its metabolites.
Observe Closely (one)modafinil will enhance the degree or influence of citalopram by affecting hepatic enzyme CYP2C19 metabolism. Use Caution/Watch. Citalopram 20 mg/day is the most recommended dose for sufferers using CYP2C19 inhibitors due to the chance of QT more information prolongation.
From postmarketing encounter, there have already been reviews of fatal overdoses involving modafinil alone or in combination with other drugs. Symptoms most frequently accompanying PROVIGIL